Thermo Fisher Scientific ABCA4 Polyclonal Antibody
ABCA4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간·생쥐·랫트 시료에 반응합니다. Western blot, ELISA, IHC(F) 등에 사용 가능하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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- PA587983
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| ELISA | 1 µg/mL | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 110–300 of human ABCA4 (NP_0003412) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.56 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804563 |
Product Specific Information
- Positive Samples: U-251MG, BT-474, 293T, Mouse heart, Mouse lung, Rat eye
- Cellular Location: Membrane, Multi-pass membrane protein
Immunogen sequence:
QELLMNAPES QHLGRIWTEL HILSQFMDTL RTHPERIAGR GIRIRDILKD EETLTLFLIK NIGLSDSVVY LLINSQVRPE QFAHGVPDLA LKDIACSEAL LERFIIFSQR RGAKTVRYAL CSLSQGTLQW IEDTLYANVD FFKLFRVLPT LLDSRSQGIN LRSWGGILSD MSPRIQEFIH RPSMQDLLWV T
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein encoded by the ABCA4 gene in humans. It belongs to the ABC transporter gene sub-family A (ABC1), found exclusively in multicellular eukaryotes.
This gene is mapped to chromosome 1p21–p13 and is expressed exclusively in retina photoreceptor cells, mediating the transport of essential molecules across the photoreceptor cell membrane.
Immunofluorescence and Western blot analyses show ABCR presence in foveal and peripheral cone and rod photoreceptors.
Loss of central vision in Stargardt macular dystrophy is associated with ABCR-mediated foveal cone degeneration.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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