Thermo Fisher Scientific IL31RA Polyclonal Antibody
IL31RA 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. Human 시료 반응성, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL31RA (Accession Q8NI17), corresponding to amino acid residues K548–T598 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818756 |
Product Specific Information
Antibody detects endogenous levels of total IL31R.
Target Information
IL-31 is a T cell cytokine preferentially produced by T helper type 2 cells.
IL-31 signals through a heterodimeric receptor composed of IL-31 receptor (IL-31R) and oncostatin M receptor (OSM).
This receptor complex recruits JAK1, JAK2, Stat1, Stat3, and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade.
SHP-2 and Shc adapter molecules are also recruited, contributing to activation of the MAP kinase pathway in response to IL-31.
Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD).
Comparisons between skin from patients with AD and healthy skin showed higher IL-31R expression on epidermal keratinocytes in AD samples.
Infiltrating cells in AD skin expressed IL-31 mRNA, suggesting IL-31 may participate in itch sensation and scratching behavior, representing a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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