Thermo Fisher Scientific GTPase HRAS Polyclonal Antibody, Biotin
Rabbit polyclonal antibody targeting human GTPase HRAS, biotin-conjugated for enhanced detection. Validated for WB, ELISA, and IP applications. Affinity purified, supplied in stabilizing buffer with BSA and glycerol. For research use only.
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- P21RAS112BIOTIN
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 100–150 on human GTPase HRAS protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways that regulate distinct cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are found in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression promotes proliferation and inhibits apoptosis.
- K-Ras mutations: common in pancreatic, colorectal, and non–small-cell lung carcinomas
- H-Ras mutations: common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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