Thermo Fisher Scientific Junin mammarenavirus Nucleoprotein Polyclonal Antibody

Thermo Fisher Scientific Junin mammarenavirus Nucleoprotein Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:5,000

Publications: (정보 없음)

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative-strand RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation. Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.