Thermo Fisher Scientific Epstein Barr Virus LMP2 Polyclonal Antibody

Thermo Fisher Scientific Epstein Barr Virus LMP2 Polyclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

Epstein-Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually result in infectious mononucleosis (glandular fever), but the virus can also lay dormant in B lymphocytes and, when reactivated, become associated with more serious diseases such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease.

EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A, and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, functioning as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV-immortalized B cells in vitro and may play an important role in maintaining latent EBV infection within peripheral blood B cells of infected individuals.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.