Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 CtIP(RBBP8)에 특이적이며 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RBBP8 (CtIP). Recombinant protein control fragment (Product #RP-106429). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791285 |
Product Specific Information
Immunogen sequence:
FSAIQRQEKS QGSETSKNKF RQVTLYEALK TIPKGFSSSR KASDGNCTLP KDSPGEPCSQ ECIILQPLNK CSPDNKPSLQ IKEENAVFKI PLRPRESLET E
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription.
Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains, suggesting that CtIP is a potential tumor suppressor.
The CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745; mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-84133_CtIP_Q99708-1_Rabbit.svg, PA5-84133_CtIP_Q99708-1_Rabbit_PDP.jpeg)
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