Thermo Fisher Scientific 53BP1 Polyclonal Antibody
53BP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피 정제. 연구용으로 DNA 손상 반응 및 종양 억제 기전 연구에 적합.
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Thermo Fisher Scientific 53BP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment (amino acids 1–229 of 53BP1, Uniprot ID#Q12888) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552027 |
Product Specific Information
- Recommended positive controls: 293T, HeLa, Neuro 2A, C8D30, NIH-3T3
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically double-strand breaks. It may participate in checkpoint signaling during mitosis, enhance TP53-mediated transcriptional activation, and contribute to DNA repair by maintaining genomic stability.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-34675_53BP1_Q12888-1_Rabbit.svg, PA5-34675_53BP1_Q12888-1_Rabbit_PDP.jpeg)
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