Thermo Fisher Scientific TLK2 Polyclonal Antibody
TLK2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 고순도(>95%)로 정제되어 신뢰성 높은 결과 제공. 세포주기 관련 연구 및 DNA 손상 반응 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human TLK2 (aa 1–772) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720746 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation. It also participates in intracellular signaling, protein phosphorylation, cell cycle progression, chromatin modification, and DNA damage response.
TLK2 shows maximal activity during the S phase of the cell cycle and is regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication results in rapid loss of TLK2 activity, indicating its function is tightly linked to DNA replication. TLK2 is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1.
This nuclear protein is widely expressed in fetal placenta, liver, kidney, pancreas, heart, skeletal muscle, and several adult cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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