Thermo Fisher Scientific p14ARF Polyclonal Antibody
인간 p14ARF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC 및 ICC/IF에 사용 가능. 단백질 A로 정제된 액상 형태로 제공되며 PBS와 1% BSA, 0.09% sodium azide 포함. 종양 억제 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of Human p14ARF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1959155 |
Product Specific Information
Recommended positive controls: Suitable tissue control sections for Immunohistochemistry — Cervical carcinoma or breast fibroadenoma.
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein ARF (p14ARF in human and P19ARF in mouse).
These proteins interact with upstream tumor suppressors — retinoblastoma protein and p53 — each playing roles in cellular senescence, cell cycle control, and tumor suppression.
p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest dependent on functional p53. The functional differences between mouse and human ARF proteins may contribute to species-specific tumor susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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