Thermo Fisher Scientific PATZ1 Polyclonal Antibody
PATZ1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot에 적합하며, 인간과 생쥐 시료에 반응합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PATZ1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human POZ (BTB) and AT hook containing zinc finger 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636173 |
Product Specific Information
The antibody detects endogenous levels of total PATZ1 protein.
Target Information
The PATZ1 gene encodes a protein containing an A-T hook DNA binding motif that interacts with other DNA-binding structures, playing an important role in chromatin remodeling and transcription regulation. The POZ domain mediates protein-protein interactions required for transcriptional repression, while zinc fingers comprise the DNA-binding domain. PATZ1 functions as a transcriptional repressor. In small round cell sarcoma, PATZ1 is fused to EWS by inversion of 22q, forming a chimeric gene (t(1;22)(p36.1;q12)) that combines the transactivation domain of EWS with the zinc finger domain of PATZ1. Four alternatively spliced transcript variants are known.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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