Thermo Fisher Scientific CD45RB Monoclonal Antibody (MEM-55), Alexa Fluor 647

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• 1:100

Flow Cytometry (Flow)

• 4 µL × 100 µL whole blood or 10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes a sialidase-sensitive extracellular epitope of CD45RB, a 180–240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform).
CD45RB is expressed on subsets of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes, and dendritic cells.

Target Information

CD45RB is a receptor-type protein tyrosine phosphatase and a CD45 glycoprotein isoform.
CD45 plays a crucial role in lymphocyte development and antigen signaling by regulating Src-family kinases.
It promotes cell survival via integrin-mediated signal transduction and participates in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic regions.
Expression patterns vary by cell type and physiological state.
CD45RB is expressed in microglia and inflammatory cells and is essential for immunoreceptor signaling and hematopoietic lineage cell function (except mature red cells).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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