Thermo Fisher Scientific GSK-3b Polyclonal Antibody
GSK-3β 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 에너지 대사 및 Wnt 신호전달 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide surrounding the epitope -NVSYI- without phosphorylation at Tyr216 of human GSK3-beta protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Positive control: Human breast adenocarcinoma
- Cellular location: Cytoplasm, Nucleus, Cell membrane
Target Information
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It negatively regulates glucose homeostasis and participates in processes such as energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptosis.
GSK3B is a critical component of the Wnt/β-catenin signaling pathway, where its activity inhibits Wnt signaling by mediating β-catenin degradation. It is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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