Thermo Fisher Scientific DDR2 Polyclonal Antibody
DDR2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 628–855 of Human DDR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2545228 |
Product Specific Information
- Recommended positive controls: Raji, mouse brain
- Predicted reactivity: Mouse (97%), Rat (97%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DDR2 is a member of a subclass of receptor tyrosine kinases (RTKs) and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 are potently inhibited by Gleevec. DDR2 is required for normal bone development and regulates osteoblast differentiation and chondrocyte maturation via MAP kinase signaling, leading to activation of RUNX2. It also regulates extracellular matrix remodeling by upregulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and tumor invasion. DDR2 promotes fibroblast migration and proliferation, contributing to cutaneous wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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