Thermo Fisher Scientific FNTA Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

FNTA (Farnesyltransferase, CAAX box; alpha CAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).
Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The CAAX farnesyl transferase (EC 2.5.1.21) is an alpha-beta heterodimeric enzyme that catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box.
FNTA, the alpha subunit of farnesyl transferase, is shared by geranyl-geranyl protein transferases. In addition to transferring farnesyl and geranyl groups to proteins, FNTA may regulate intracellular signaling pathways involving p21ras. Reports indicate that FNTA interacts with TGF-beta and activin-type I receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.