Thermo Fisher Scientific FNTA Polyclonal Antibody
FNTA 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP 등에 사용 가능. 1 mg/mL 액상 형태이며 4°C 보관. FFPE 조직에서는 citrate buffer(pH 6.0) 전처리 권장. 연구용으로만 사용.
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- A304267Ax (2개 옵션)
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 329 to 379 of human Farnesyltransferase, CAAX Box, Alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
FNTA (Farnesyltransferase, CAAX box; alpha CAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/geranyl geranyl transferase type I alpha subunit (PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located at locus 8p11 (human).
Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The CAAX farnesyl transferase (EC 2.5.1.21) is an alpha-beta heterodimeric enzyme that catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box.
FNTA, the alpha subunit of farnesyl transferase, is shared by geranyl-geranyl protein transferases. In addition to transferring farnesyl and geranyl groups to proteins, FNTA may regulate intracellular signaling pathways involving p21ras. Reports indicate that FNTA interacts with TGF-beta and activin-type I receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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