Thermo Fisher Scientific Cerebral Protein 1 Polyclonal Antibody
Human Cerebral Protein 1을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 저장용액에 포함. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RRP8 (Cerebral Protein 1, UniProt ID: O43159-1, antigen range 158–256, length 456 aa). Recombinant protein control fragment (Product #RP-105076). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791503 |
Product Specific Information
Immunogen sequence:
AWKGSTTNDP PKQSPGSTSP KPPHTLSRKQ WRNRQKNKRR CKNKFQPPQV PDQAPAEAPT EKTEVSPVPR TDSHEARAGA LRARMAQRLD GARFRYLNE
Target Information
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, which mediates silencing of rDNA in response to intracellular energy status by recruiting histone-modifying enzymes. Upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation and subsequent dimethylation at Lys-9 (H3K9me2) by SUV39H1, forming silent chromatin in the rDNA locus. RRP8 binds H3K9me2 and likely acts as a methyltransferase, though its substrates remain unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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