Thermo Fisher Scientific p130Cas Polyclonal Antibody
Thermo Fisher Scientific의 p130Cas Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western blot, IHC, ICC/IF에 적합합니다. 합성 펩타이드 면역원으로 제작된 고순도 항체로, 세포 부착 및 신호전달 연구에 활용됩니다. 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCAR1 (Accession P56945), corresponding to amino acid residues G384–S434 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818469 |
Product Specific Information
Antibody detects endogenous levels of total p130Cas.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signaling via v-Crk and v-Src oncoproteins.
It contains a Src homology (SH)-3 domain, multiple YXXP motifs, and a proline-rich region.
p130Cas is involved in biological processes such as cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection.
Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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