Thermo Fisher Scientific Nicotinic Acetylcholine Receptor alpha 7 subunit 2 Polyclonal Antibody
Rabbit polyclonal antibody against Nicotinic Acetylcholine Receptor alpha 7 subunit (CHRNA7). Validated for WB, IHC, ELISA, and IP. Reacts with mouse and rat. Affinity purified, supplied in liquid form with glycerol and BSA. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 25–75 on mouse GTPCHI protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein belonging to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, mediating signal transmission at synapses. CHRFAM7A is expressed in the hippocampus, and alternative splicing of the CHRFAM7A gene produces two splice variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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