Thermo Fisher Scientific SCNN1B Polyclonal Antibody
SCNN1B 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB 및 IHC에 사용 가능하며, 인간 종에 반응. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human SCNN1B conjugated to a carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCNN1B.
Target Information
SCNN1B encodes a sodium-permeable, non-voltage-sensitive ion channel inhibited by the diuretic amiloride.
This channel mediates sodium and water transport through epithelial cell membranes and regulates sodium reabsorption in kidney, colon, lung, and sweat glands. It also contributes to taste perception.
- Structure: Heterotetramer of two alpha, one beta, and one gamma subunit.
- Interactions: Binds WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
- Clinical relevance:
- Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1), a severe salt-wasting disease.
- Also implicated in Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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