Thermo Fisher Scientific SLC8A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity of this antibody: SLC8A1.

Target Information

Ca²⁺ plays a critical role in intracellular signaling, and regulation of calcium balance is essential for maintaining this function. The plasma membrane Na⁺/Ca²⁺ exchangers (NaCX) mediate Na⁺-dependent Ca²⁺ efflux in various cell types. NaCX can move Ca²⁺ into or out of cells depending on the net Na⁺, Ca²⁺, and K⁺ gradients across the membrane.

In mammals, at least five distinct genes code for these exchangers: three NaCX (NaCX-1, NaCX-2, NaCX-3) and two NaCKX (NaCKX-1, NaCKX-2). NaCX-1 is most prominently expressed in the heart, playing a major role in excitation-contraction coupling. NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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