Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Monoclonal Antibody (CFTR, 1643)

Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Monoclonal Antibody (CFTR, 1643)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport.
CF typically results in severe lung and liver disease. Interestingly, CFTR also serves as an entry point for Salmonella typhi into intestinal epithelial cells, and ΔF508 heterozygous and homozygous mice show 86% and 100% reductions in S. typhi intestinal submucosal uptake, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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