Thermo Fisher Scientific ATG16L1 Monoclonal Antibody (OTI2A10), TrueMAB
ATG16L1 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 적합. 인간 시료에 반응하며 액상 형태로 제공. PBS/BSA/glycerol buffer에 보관하며 -20°C에서 안정적. 자가포식 관련 연구용으로 사용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–277 of human ATG16L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Autophagy related protein 16L is encoded by the ATG16L gene located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate and oligomerize with ATG16L to form an 800 kDa Atg16L complex, which facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE). This ubiquitin-like conjugation system is a widely used marker for autophagy.
The ATG16L complex, along with other ATGs such as ATG18 and ATG21, prevents premature cleavage of ATG8-PE by the cysteine protease Atg4 until the autophagosome is complete.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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