Thermo Fisher Scientific BNC1 Polyclonal Antibody
Mouse BNC1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 사용 가능. Affinity chromatography로 정제된 액상 형태이며, PBS와 sucrose buffer에 보관. 세포 분화 및 핵-세포질 이동 연구에 적합.
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Applications
- Western Blot (WB): 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of mouse BNC1 (UniProt ID: O35914-1, antigen range: 752–801) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688999 |
Product Specific Information
This target displays homology in the following species:
Dog: 86% · Guinea Pig: 93% · Horse: 93% · Human: 100% · Mouse: 100% · Pig: 100% · Rabbit: 100% · Rat: 100%
Target Information
Bnc1 is a 994 amino acid transcription factor specific for squamous epithelium and keratinocytes at early terminal differentiation stages. It is a zinc finger protein with three separated pairs of zinc fingers and a nuclear localization signal. Bnc1 shuttles between nucleus and cytoplasm depending on cell proliferation potential. Phosphorylation on Ser-537 and Ser-541 induces cytoplasmic localization. It is found in basal cell layers of epidermis, hair follicles, and germ cells of testis and ovary, with lower expression in thymus, spleen, mammary glands, placenta, brain, and heart. It plays a regulatory role in keratinocyte proliferation and rRNA transcription, and is involved in spermatozoa and oocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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