Thermo Fisher Scientific native NGF Polyclonal Antibody
Rabbit polyclonal antibody recognizing native NGF. Western blot, IHC, inhibition assay에 적합. Human, mouse, rat 반응성. Lyophilized 형태, 4°C 또는 -20°C 보관. 연구용으로 신경 성장 인자 관련 연구에 활용 가능.
- 카탈로그번호
- OSN00001W-150UL
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- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Inhibition Assays (IA) | 1:100 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Native beta-nerve growth factor (Ngfb, beta-NGF) purified from mouse submandibular gland |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: NGF.
Target Information
Nerve growth factor (NGF) influences the survival and differentiation of various neuronal and non-neuronal cells. NGF binds to specific cell surface receptors with high and low affinity; only the high-affinity form is capable of signal transduction.
Cross-linking studies with ¹²⁵I-NGF have shown that the high-affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF, while the low-affinity receptor forms an Mr 100,000 complex.
Full-length cDNA clones for both human and rat NGF receptor genes show over 90% homology between species. NGF promotes nerve growth and differentiation of sympathetic and sensory neurons.
Mutations in the NGF gene are linked to hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulated NGF expression is associated with allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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