Thermo Fisher Scientific POLR3D Polyclonal Antibody
Rabbit polyclonal antibody targeting Human POLR3D, suitable for IHC and IHC (Paraffin) applications. Affinity-purified and supplied as liquid form at 0.10 mg/mL concentration. Predicted cross-reactivity with Gorilla and Chimpanzee. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human DNA-directed RNA polymerase III subunit D |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Gorilla and Chimpanzee
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It binds BRCA1 both in vivo and in vitro and shares homology with the two most conserved BRCA1 regions: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif, a cysteine-rich sequence, is found in proteins regulating cell growth, including tumor suppressor and proto-oncogene products. This protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting that stable complex formation between these proteins is essential for BRCA1 tumor suppression. This protein may be a target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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