Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (Bcl2/100), FITC

Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (Bcl2/100), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 4 µL / 1×10⁶ cells
  View 2 publications

Product Specifications

Additional Formats

• PE Conjugate
• Request custom conjugation

Product Specific Information

This antibody recognizes Bcl-2, a 26 kDa intracellular proto-oncogene with anti-apoptotic effect.
It is expressed in the outer mitochondrial membrane, endoplasmic reticulum, and nuclear envelope.

Target Information

BCL-2 is a key regulator of apoptosis that can inhibit or promote cell death.
Members of the BCL-2 family form dimers to modulate apoptosis.

• Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
• Bax and Bak promote cytochrome c release, initiating apoptosis.

Constitutive expression of BCL-2, such as through translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas normal centers are negative.
Two transcript variants of BCL-2 differ in their C-terminal ends.
Overexpression of BCL-2 has been linked to B-cell lymphoma and prostate cancer.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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