Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 20 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• FITC
• Custom conjugation available upon request

Target Information

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
CD18 forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (β2) integrins:

• αLβ2 (CD11a/CD18, LFA-1)
• αMβ2 (CD11b/CD18, Mac-1, CR3)
• αXβ2 (CD11c/CD18)
• αDβ2 (CD11d/CD18)

These integrins are essential for leukocyte migration and intercellular adhesion.
Defects in CD18 lead to leukocyte adhesion deficiency type I (LAD1).
CD18 also mediates leukotoxin-induced cytolysis by Mannheimia haemolytica.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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