Thermo Fisher Scientific Caspr2 Polyclonal Antibody
Caspr2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, Flow cytometry, ELISA에 사용 가능. Human 및 Rat 시료에 반응하며, 고순도의 Protein A 정제 항체. 신경세포 접착 및 발달 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Caspr2, amino acids 801–900 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Caspr2 gene encodes a member of the neurexin family functioning in the vertebrate nervous system as a cell adhesion molecule and receptor. This protein contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a PDZ binding site. It is localized at the juxtaparanodes of myelinated axons and mediates neuron–glia interactions during nervous system development. Caspr2 is involved in potassium channel localization within differentiating axons and is regulated by FOXP2, a transcription factor related to speech and language development. Mutations or dysregulation are associated with neurodevelopmental disorders including Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and intellectual disability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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