Thermo Fisher Scientific GCH1 Polyclonal Antibody
Thermo Fisher Scientific의 GCH1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 항체로, WB, ICC/IF, ELISA에 적합합니다. 재조합 GCH1 단백질(aa 55–250)을 면역원으로 사용하며, 액상 형태로 -20°C 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 55–250 of human GCH1 (NP_000152.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913670 |
Product Specific Information
- Positive test controls: THP-1, Mouse liver, Mouse brain, Mouse spleen, Rat lung, Rat liver
- Target localization: Cytoplasm, Nucleus
Immunogen sequence:
GERPRSEEDN ELNLPNLAAA YSSILSSLGE NPQRQGLLKT PWRAASAMQF FTKGYQETIS DVLNDAIFDE DHDEMVIVKD IDMFSMCEHH LVPFVGKVHI GYLPNKQVLG LSKLARIVEI YSRRLQVQER LTKQIAVAIT EALRPAGVGV VVEATHMCMV MRGVQKMNSK TVTSTMLGVF REDPKTREEF LTLIRS
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases and nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, though not all are functional.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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