Thermo Fisher Scientific IL-28A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total IL-28A.

Target Information

IL-28A belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), also known as type III Interferons.

The IFN lambdas signal through a heterodimeric receptor composed of IL-10R2 and IFN lambda R1 (IL-28R alpha). Signaling occurs via the Jak/STAT pathway, similar to type I IFN signaling, activating many of the same genes despite low sequence homology. Both IFN families exhibit antiviral, antiproliferative, and antitumor effects, making IFN lambda a potential alternative to IFN alpha therapies.

Unlike type I IFNs, which stimulate most cells, IFN lambda responses are limited to dendritic and some tumor cells due to restricted receptor expression. IFN lambda stimulation can also promote the differentiation of dendritic cells toward CD4⁺CD25⁺FoxP3⁺ regulatory T cells, suggesting an immunoregulatory role.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.