Thermo Fisher Scientific Phospho-4EBP1 (Thr46) Polyclonal Antibody
4EBP1 단백질의 Thr46 인산화 형태를 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 사용 가능. 인산화 신호전달 연구에 적합하며, 다양한 종에서 보존된 서열 기반 면역원 사용. 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Published species | Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human 4E-BP1 that contains threonine 46. The sequence is conserved in human, mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533587 |
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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