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Thermo Fisher Scientific SMURF2 Polyclonal Antibody
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SMURF2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, Human 시료 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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마지막 업데이트 2025. 08. 05. 오후 03:29
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Thermo Fisher Scientific PA588008 SMURF2 Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
618,800원VAT 포함 680,680원
Thermo Fisher Scientific · Thermo Fisher Scientific SMURF2 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 150–250 of human SMURF2 (NP_0735761) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.39 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804584 |
Product Specific Information
- Immunogen sequence: DCSRLFDNDL PDGWEERRTA SGRIQYLNHI TRTTQWERPT RPASEYSSPG RPLSCFVDEN TPISGTNGAT CGQSSDPRLA ERRVRSQRHR NYMSRTHLHT P
- Positive Samples: SW480
- Cellular Location: Cell membrane, Cytoplasm, Membrane raft, Nucleus
Target Information
SMURF2 is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers it to target substrates. It interacts with SMAD1, SMAD2, and SMAD7 to trigger their ubiquitination and proteasome-dependent degradation. SMURF2 enhances SMAD7 inhibitory activity and reduces SMAD2 transcriptional activity. Coexpression with SMAD1 decreases SMAD1 protein levels and slightly reduces SMAD2 levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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