ELK Biotechnology Cdc2 rabbit pAb
CDK1(Cdc2) 단백질을 인식하는 rabbit polyclonal antibody로, WB·IP·ELISA에 적합합니다. 인간 CDC2 유래 합성 펩타이드로 면역하여 제작되었으며, 핵·세포질·미토콘드리아 등 다양한 세포소기관에서 발현을 검출할 수 있습니다. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능합니다.
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제품명
Cdc2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase |
| Applications | WB; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IP: 1/50 - 1/200 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDC2 (AA range: 131–180) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| GeneID (Human) | 983 |
| Human Swiss-Prot No | P06493 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치 (Cellular Localization)
Nucleus, cytoplasm, and mitochondrion.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, and spindle.
Cytoplasmic during interphase; colocalizes with SIRT2 on centrosome during prophase and on spindle fibers during metaphase of mitotic cycle.
Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1.
Accumulates in mitochondria in G2-arrested cells upon DNA damage.
단백질 배경 (Background)
Cyclin dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family and serves as the catalytic subunit of M-phase promoting factor (MPF), essential for G1/S and G2/M phase transitions in the eukaryotic cell cycle.
Mitotic cyclins associate with CDK1 as regulatory subunits, controlling kinase activity through cyclin accumulation and degradation.
Phosphorylation and dephosphorylation of CDK1 play critical roles in cell cycle regulation.
Alternatively spliced transcript variants encoding different isoforms have been identified.
[provided by RefSeq, Mar 2009]
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