ELK Biotechnology AQP2 rabbit pAb
AQP2 rabbit polyclonal antibody로 인간, 마우스, 랫트 등에서 반응. WB, IHC, IF, ELISA에 사용 가능. 신장 집합관의 수분 채널 단백질 인식. 고순도 IgG, -20°C에서 1년 안정 저장.
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제품명
AQP2 rabbit pAb
대체 명칭
AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
적용 분야
WB, IHC, IF, ELISA
권장 희석 배율
- Western Blot: 1/500 - 1/2000
- Immunohistochemistry: 1/100 - 1/300
- Immunofluorescence: 1/200 - 1/1000
- ELISA: 1/10000
(기타 응용 분야에서는 아직 테스트되지 않음)
면역원
Synthesized peptide derived from human Aquaporin 2 (AA range: 222–271)
제품 정보
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 29 kD |
| GeneID (Human) | 359 |
| Human Swiss-Prot No | P41181 |
| Species Reactivity | Human, Mouse, Rat, Monkey, Dog |
| Host | Rabbit |
| Storage | -20°C / 1 year |
세포 내 위치
Apical cell membrane; Multi-pass membrane protein
Basolateral cell membrane; Multi-pass membrane protein
Cell membrane; Multi-pass membrane protein
Cytoplasmic vesicle membrane; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein
Shuttles from vesicles to the apical membrane (PubMed:15509592).
Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592).
PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity).
배경 정보
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. (provided by RefSeq, Oct 2008)
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