ELK Biotechnology Caspase-9 rabbit pAb
Caspase-9 rabbit pAb는 인간, 마우스, 랫트에 반응하는 다클론 항체로, 세포 사멸 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능하며, 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관됩니다.
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제품명
Caspase-9 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 9 (AA range: 91–140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 46 kD |
| GeneID (Human) | 842 |
| Human Swiss-Prot No | P55211 |
| Cellular Localization | nucleus, mitochondrion, cytosol, apoptosome |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.
This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade.
This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, May 2013]
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