ELK Biotechnology c-Abl rabbit pAb
Human ABL1 유래 펩타이드로부터 제작된 rabbit polyclonal antibody로, WB, IHC, IF, ELISA 등 다양한 응용에 적합. 세포질, 핵, 미토콘드리아에 위치하며 BCR-ABL 복합체 검출 가능. -20°C에서 1년 안정 저장.
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ELK Biotechnology c-Abl rabbit pAb
제품 개요
Human ABL1 유래 합성 펩타이드(AA 861–910)를 면역원으로 제작된 rabbit polyclonal antibody입니다.
세포질, 핵, 미토콘드리아 등 다양한 세포 부위에서 발현되는 c-Abl 단백질 검출에 사용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | c-Abl rabbit pAb |
| Alternative Names | ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human ABL1 (AA range: 861–910) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kDa (200 kDa BCR-ABL complex) |
| GeneID (Human) | 25 |
| Human Swiss-Prot No | P00519 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cytoskeleton, nucleus, mitochondrion.
Shuttles between the nucleus and cytoplasm depending on environmental signals.
Sequestered into the cytoplasm through interaction with 14-3-3 proteins.
Localizes to mitochondria in response to oxidative stress.
Isoform IB: nucleus membrane; lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
Background
This gene encodes a proto-oncogene protein tyrosine kinase involved in cell division, adhesion, differentiation, and stress response.
Its activity is negatively regulated by the SH3 domain, and deletion of this domain results in oncogenic transformation.
The protein exhibits DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
Fusion with partner genes (notably BCR in t(9;22) translocation) is associated with various leukemias.
Alternative splicing produces two transcript variants with distinct first exons.
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