
ELK Biotechnology Bcr rabbit pAb
인간 및 마우스 반응성을 가진 Bcr rabbit polyclonal antibody로 WB, IHC, IF, ELISA에 적합합니다. 인간 Bcr 유래 합성 펩타이드로 면역화되었으며, 고순도 IgG 형태로 제공됩니다. 세포 접합부 및 시냅스 등에서 Bcr 단백질 검출에 유용합니다.
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제품명
Bcr rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Bcr 단백질을 인식하는 rabbit polyclonal antibody로, 인간 및 마우스 시료에서 Western blot, Immunohistochemistry, Immunofluorescence, ELISA 등 다양한 응용에 적합합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | BCR; BCR1; D22S11; Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human Bcr (AA range: 144–193) |
| Host Species | Rabbit |
| Storage Conditions | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 143 kDa |
| Gene ID (Human) | 613 |
| Human Swiss-Prot No. | P11274 |
| Cellular Localization | Cell junction, synapse, postsynaptic density, dendritic spine, axon |
| Species Reactivity | Human; Mouse |
Background
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in chronic myelogenous leukemia. The chromosome 22 breakpoint occurs within the BCR gene, resulting in a fusion protein encoded by both BCR and ABL sequences. While the BCR-ABL fusion protein is well studied, the normal BCR protein’s function remains less clear. It exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
(Source: RefSeq, Jul 2008)
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