ELK Biotechnology Akt1 (phospho Ser129) rabbit pAb
Akt1 (phospho Ser129) rabbit polyclonal antibody for WB and ELISA applications. Recognizes phosphorylated Akt1 at Ser129. Suitable for human, mouse, and rat samples. High specificity and sensitivity for Akt signaling studies.
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Akt1 (phospho Ser129) rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 Akt1 (phospho Ser129) rabbit polyclonal antibody는 인간 Akt 단백질의 Ser129 인산화 부위 주변 합성 펩타이드로부터 생산된 항혈청입니다. Akt 신호 전달 및 세포 생존 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Akt1 (phospho Ser129) rabbit pAb |
| Alternative Names | AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Akt around the phosphorylation site of Ser129 (AA range: 95–144) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 207 |
| Human Swiss-Prot No | P31749 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, nucleus, and cell membrane. Nucleus localization occurs after activation by ILK1. Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 leads to membrane localization for further activation at Thr-308 and Ser-473. Activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).
Background
The AKT1 gene encodes a serine-threonine protein kinase that is inactive in serum-starved fibroblasts but activated by platelet-derived growth factor via phosphatidylinositol 3-kinase. AKT1 mediates growth factor-induced neuronal survival and suppresses apoptosis through phosphorylation of apoptotic components. Mutations in AKT1 are linked to Proteus syndrome. Multiple alternatively spliced transcript variants exist for this gene. [RefSeq, Jul 2011]
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