ELK Biotechnology Bcl-x rabbit pAb
Bcl-x rabbit polyclonal antibody로 인간, 생쥐, 랫트 시료에 반응합니다. WB, IHC, IF, ELISA에 적합하며, 미토콘드리아 및 세포막 단백질 검출에 유용합니다. 고순도 IgG, 1 mg/ml 농도로 제공되며 -20°C에서 1년 보관 가능합니다.
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제품명
Bcl-x rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BCL-XL (AA range: 13-62) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kD |
| GeneID (Human) | 598 |
| Human Swiss-Prot No | Q07817 |
| Cellular Localization | Isoform Bcl-X(L): Mitochondrion inner membrane, outer membrane, matrix, cytoplasmic vesicle (secretory, synaptic), cytosol, cytoskeleton (microtubule organizing center, centrosome), nucleus membrane (cytoplasmic side). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. Localizes to the centrosome when phosphorylated at Ser-49. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. These proteins are located at the outer mitochondrial membrane and regulate the mitochondrial membrane channel (VDAC) opening. VDAC controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — key in cell apoptosis. Alternative splicing results in multiple transcript variants encoding two isoforms: the longer isoform acts as an apoptotic inhibitor, and the shorter isoform acts as an apoptotic activator. (RefSeq, Dec 2015)
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