ELK Biotechnology Arrestin-β-1 rabbit pAb
Arrestin-β-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 유래 합성 펩타이드로 면역화. 세포질 및 핵에서 발현되는 Arrestin-β-1 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
Arrestin-β-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Arrestin 1 (AA range: 369-418) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 47 kD |
| Gene ID (Human) | 408 |
| Human Swiss-Prot No. | P49407 |
| Cellular Localization | Cytoplasm, nucleus, cell membrane, clathrin-coated pit, pseudopodium, cytoplasmic vesicle. Translocates to plasma membrane and colocalizes with antagonist-stimulated GPCRs. Monomeric form: nucleus; oligomeric form: cytoplasm. Translocates to nucleus upon OPRD1 stimulation (By similarity). |
| Species Reactivity | Human; Monkey |
Background
Members of the arrestin/beta-arrestin protein family participate in agonist-mediated desensitization of G-protein-coupled receptors, attenuating cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta-1 is a cytosolic protein acting as a cofactor in beta-adrenergic receptor kinase (BARK)-mediated desensitization of beta-adrenergic receptors. It is expressed at high levels in peripheral blood leukocytes as well as in the central nervous system, suggesting a role in receptor-mediated immune regulation. Alternatively spliced transcripts encoding different isoforms of arrestin beta-1 have been described.
[provided by RefSeq, Jan 2011]
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