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ELK Biotechnology Tau (phospho Ser404) rabbit pAb
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Tau 단백질의 Ser404 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB와 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 신경퇴행성 질환 연구에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
- 판매단위
- pk
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ELK Biotechnology ES1413-100UL Tau (phospho Ser404) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES1413-50UL Tau (phospho Ser404) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Tau (phospho Ser404) rabbit pAb
Tau (phospho Ser404) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Tau (phospho Ser404) rabbit pAb |
| Alternative Names | MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Ser404. AA range: 691-740 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50–85 kD |
| Gene ID (Human) | 4137 |
| Human Swiss-Prot No. | P10636 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytosol. Cell membrane (peripheral membrane protein, cytoplasmic side). Cytoplasm, cytoskeleton. Cell projection (axon, dendrite). Secreted. Mostly found in axons of neurons, in the cytosol and associated with plasma membrane components (PubMed:10747907). Can be secreted; secretion depends on protein unfolding and is facilitated by cargo receptor TMED10, resulting in translocation from cytoplasm into ERGIC followed by vesicle entry and secretion (PubMed:32272059). |
| Background | This gene encodes the microtubule-associated protein tau (MAPT), whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on neuronal maturation stage and neuron type. MAPT gene mutations are associated with neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy (RefSeq, Jul 2008). |
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