ELK Biotechnology APLP-2 rabbit pAb
APLP-2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, Alzheimer 연구 등에서 활용. -20°C에서 1년 보관 가능.
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제품명
APLP-2 rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human APLP2 (AA range: 241–290) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 87 kD |
| GeneID (Human) | 334 |
| Human Swiss-Prot No | Q06481 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes amyloid precursor-like protein 2 (APLP2), a member of the APP (amyloid precursor protein) family including APP, APLP1, and APLP2. This protein is ubiquitously expressed and contains heparin-, copper-, and zinc-binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. It interacts with major histocompatibility complex (MHC) class I molecules. The synergy between APLP2 and APP is required to mediate neuromuscular transmission, spatial learning, and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer’s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
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