ELK Biotechnology AIRE-1 rabbit pAb
AIRE-1 rabbit polyclonal antibody for WB, IF, and ELISA applications. Targets human AIRE protein involved in immune regulation. High specificity with nuclear and cytoplasmic localization. Long-term storage at -20°C, 1 mg/ml concentration.
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ELK Biotechnology AIRE-1 rabbit pAb
제품 개요
AIRE-1 rabbit polyclonal antibody는 인간 AIRE 단백질을 인식하며, 자가면역 반응 조절에 중요한 역할을 하는 단백질 연구에 적합합니다. Western blot, Immunofluorescence, ELISA 등 다양한 응용에 사용 가능합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | AIRE-1 rabbit pAb |
| Alternative Names | AIRE; APECED; Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APECED protein |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AIRE (AA range: 91–140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 326 |
| Human Swiss-Prot No | O43918 |
| Cellular Localization | Nucleus, Cytoplasm. Predominantly nuclear but also cytoplasmic. Found in nuclear body-like structures and filamentous vimentin-like patterns. Associated with tubular structures. (PubMed:11274163, 14974083, 26084028) |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and the negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
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