ELK Biotechnology Abi-1 rabbit pAb
Abi-1 rabbit pAb는 인간, 생쥐, 랫트에 반응하는 폴리클로날 항체로, 세포질 및 신경 성장콘 등 다양한 세포 구조에서 발현되는 Abi-1 단백질을 검출합니다. WB와 ELISA에 적합하며, 세포 신호전달 및 암 연구에 활용 가능합니다.
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ELK Biotechnology Abi-1 rabbit pAb
제품 개요
Abi-1 rabbit pAb는 Abelson-interactor 단백질 패밀리 구성원 중 하나인 Abi-1을 인식하는 폴리클로날 항체로, 세포 신호전달 및 세포골격 재구성 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Abi-1 rabbit pAb |
| Alternative Names | ABI1; SSH3BP1; Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000; ELISA: 1/40000 (Other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human Abi-1 (AA range: 152–201) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 10006 |
| Human Swiss-Prot No | Q8IZP0 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, Nucleus, Cell projection (lamellipodium, filopodium, growth cone), Cell junction (synapse, postsynaptic density), Cytoplasm (cytoskeleton).
Localized to protruding lamellipodia and filopodia tips, neuronal growth cones, and synaptosomes. May shuttle between postsynaptic densities and nucleus (By similarity).
Background
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of multiprotein complexes and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases.
The encoded protein plays a role in macropinocytosis as part of the WAVE2 complex and forms a complex with EPS8 and SOS1 mediating Ras-to-Rac signal transduction.
Abi-1 may be involved in progression of malignancies such as melanoma, colon cancer, and breast cancer. A t(10;11) translocation involving this gene and MLL has been linked to acute myeloid leukemia.
Alternative splicing results in multiple isoforms, and a pseudogene is located on chromosome 14q.
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