ELK Biotechnology Catenin-β (phospho Ser552) rabbit pAb

제품명

Catenin-β (phospho Ser552) rabbit pAb

주요 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, nucleus, cytoskeleton, and cell junctions.
Localized at adherens junctions, cell membrane, centrosome, spindle pole, and cilium basal body.
Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity).
Cytoplasmic when unstabilized (high phosphorylation) or bound to CDH1.
Translocates to the nucleus when stabilized (low phosphorylation).
Interaction with GLIS2 and MUC1 promotes nuclear translocation, while interaction with EMD inhibits it.
Majority of β-catenin is localized to the cell membrane.
During interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of cent.

배경 (Background)

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs), which are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion.
It anchors the actin cytoskeleton and transmits the contact inhibition signal that halts cell division once the epithelial sheet is complete.
This protein binds to the APC gene product, which is mutated in adenomatous polyposis of the colon.
Mutations in this gene are associated with colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Aug 2016]