ELK Biotechnology Stat3 (phospho Ser727) rabbit pAb
STAT3 (phospho Ser727) 인산화 부위를 인식하는 토끼 폴리클로날 항체로, IF, WB, IHC, IP, ELISA에 적합합니다. 세포 내 STAT3 신호전달 연구 및 인산화 상태 분석에 유용하며, 사람, 생쥐, 랫드, 원숭이에 반응합니다.
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제품명
Stat3 (phospho Ser727) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor |
| Applications | IF; WB; IHC; IP; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 IP: 2–5 µg/mg lysate ELISA: 1:10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human STAT3 around the phosphorylation site of Ser727 (AA range: 694–743) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kDa |
| Gene ID (Human) | 6774 |
| Human Swiss-Prot No. | P40763 |
| Species Reactivity | Human; Mouse; Rat; Monkey |
세포 내 위치
Cytoplasm, Nucleus. Shuttles between the nucleus and cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization in response to activated FGFR1–4 signaling. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly cytoplasmic without stimuli. Upon LIF stimulation, accumulates in the nucleus. The BART–ARL2 complex is important for nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
배경 (Background)
The STAT3 protein is a member of the STAT family, activated by phosphorylation in response to cytokines and growth factors such as IFNs, EGF, IL5, IL6, HGF, LIF, and BMP2. Once activated, STAT3 forms dimers that translocate to the nucleus and act as transcription activators. It regulates expression of genes involved in cell growth and apoptosis. Rac1 binds and regulates STAT3 activity, while PIAS3 acts as a specific inhibitor. Mutations in STAT3 are associated with infantile-onset multisystem autoimmune disease and hyper-IgE syndrome.
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