ELK Biotechnology Rad17 (phospho Ser646) rabbit pAb
Rad17 단백질의 Ser646 인산화 부위를 인식하는 토끼 다클론 항체로, WB, IHC, ELISA에 사용 가능. DNA 손상 반응 및 세포주기 체크포인트 연구에 적합하며, 인간, 마우스, 랫트 시료에 반응.
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제품명
Rad17 (phospho Ser646) rabbit pAb
제품 개요
Rad17 단백질의 Ser646 인산화 부위를 특이적으로 인식하는 토끼 다클론 항체입니다. DNA 손상 반응 및 세포주기 조절 메커니즘 연구에 유용하게 사용됩니다.
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Rad17 (phospho Ser646) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 5884 |
| Human Swiss-Prot No. | O75943 |
| Cellular Localization | Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair. This protein shares similarity with DNA replication factor C (RFC) and can form a complex with RFCs. It binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. Rad17 recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. Phosphorylation of this protein is essential for DNA-damage-induced G2 arrest and is a critical early event during checkpoint signaling. Multiple alternatively spliced transcript variants encode four distinct protein isoforms.
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