ELK Biotechnology PDGFR-β (phospho Tyr1021) rabbit pAb
PDGFR-β (phospho Tyr1021) rabbit pAb는 인산화된 PDGFR-β 단백질을 검출하는 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 사람, 마우스, 랫에서 반응합니다. 세포막 및 소포 내 PDGFR-β의 위치 연구에 활용됩니다.
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PDGFR-β (phospho Tyr1021) rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 PDGFR-β (phospho Tyr1021) rabbit pAb는 인산화된 PDGFR-β 단백질을 검출하기 위한 폴리클로날 항체입니다. 세포막 및 소포 내 PDGFR-β의 위치 확인과 관련 신호전달 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFR-β (phospho Tyr1021) rabbit pAb |
| Alternative Names | PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300; ELISA: 1/5000 (Other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human PDGFR beta around phosphorylation site of Tyr1021 (AA range: 991–1040) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kD |
| GeneID (Human) | 5159 |
| Human Swiss-Prot No | P09619 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to degradation. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family, which act as mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or heterodimer composed of PDGFR alpha and beta polypeptides. Located on chromosome 5, it is flanked by genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all potentially implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses this gene with ETV6 results in chronic myeloproliferative disorder with eosinophilia. (RefSeq, Jul 2008)
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