ELK Biotechnology Cot (phospho Thr290) rabbit pAb

제품명

Cot (phospho Thr290) rabbit pAb

대체명 (Alternative Names)

MAP3K8; COT; ESTF; Mitogen-activated protein kinase kinase kinase 8; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2

적용 분야 (Applications)

• WB (Western Blot)
• IHC (Immunohistochemistry)
• IF (Immunofluorescence)
• ELISA

권장 희석 배수 (Recommended Dilutions)

• Western Blot: 1/500 – 1/2000
• Immunohistochemistry: 1/100 – 1/300
• Immunofluorescence: 1/200 – 1/1000
• ELISA: 1/40000
• Other applications: Not yet tested

면역원 (Immunogen)

The antiserum was produced against a synthesized peptide derived from human COT around the phosphorylation site of Thr290.
Amino acid range: 256–305

보관 및 안정성 (Storage)

• Host: Rabbit
• Storage condition: -20°C, stable for 1 year

항체 특성 (Antibody Characteristics)

배경 (Background)

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. It can also activate IκB kinases, inducing nuclear NF-κB production. Additionally, it promotes TNF-α and IL-2 production during T lymphocyte activation. This gene may utilize a downstream in-frame translation start codon to produce a shorter isoform with weaker transforming activity. Alternative splicing results in multiple transcript variants encoding the same protein.
[Provided by RefSeq, Sep 2011]