ELK Biotechnology c-Myc (phospho Ser62) rabbit pAb
c-Myc (phospho Ser62) rabbit polyclonal antibody로 세포 내 핵 단백질의 인산화 상태를 검출. WB, IHC, IF, ELISA에 적합하며 인간, 마우스, 랫트 반응성. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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제품명
c-Myc (phospho Ser62) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Myc around the phosphorylation site of Ser62 (AA range: 31-80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kDa (also ~60 kDa in some samples) |
| GeneID (Human) | 4609 |
| Human Swiss-Prot No | P01106 |
| Cellular Localization | Nucleus, nucleoplasm, nucleolus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. It functions as a transcription factor regulating transcription of specific target genes. Mutations, overexpression, rearrangement, and translocation of this gene have been associated with various hematopoietic tumors, leukemias, and lymphomas, including Burkitt lymphoma. Alternative translation initiations from an upstream non-AUG (CUG) and a downstream AUG start site result in two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in normal gene function. [RefSeq, Jul 2008]
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