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ELK Biotechnology Smad3 (phospho Ser208) rabbit pAb
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Smad3 단백질의 Ser208 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포질 및 핵에서 발현되며 TGF-β 신호전달 연구에 적합.
- 판매단위
- pk
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ELK Biotechnology ES1493-100UL Smad3 (phospho Ser208) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES1493-50UL Smad3 (phospho Ser208) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Smad3 (phospho Ser208) rabbit pAb
제품명
Smad3 (phospho Ser208) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
Smad3 단백질의 Ser208 인산화 부위를 인식하는 토끼 폴리클로날 항체입니다. TGF-β 신호전달 경로 연구 및 Smad3 관련 세포 내 위치 변화 분석에 유용합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Product name | Smad3 (phospho Ser208) rabbit pAb |
| Alternative Names | SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Smad3 around the phosphorylation site of Ser208 (AA range: 174–223) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| GeneID (Human) | 4088 |
| Human Swiss-Prot No | P84022 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic and nuclear in the absence of TGF-β. Upon TGF-β stimulation, migrates to the nucleus when complexed with SMAD4. Released from the SMAD2/SMAD4 complex via PPM1A and exported from the nucleus through RANBP1 interaction. Co-localizes with LEMD3 at the nuclear inner membrane. MAPK-mediated phosphorylation has no effect on nuclear import. PDPK1 prevents nuclear translocation in response to TGF-β. Mainly localized to the nucleus in early embryo development, later evident in cytoplasm of the inner cell mass at the blastocyst stage. |
| Background | The SMAD3 protein belongs to the SMAD family, homologous to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways. SMAD3 acts as a transcriptional modulator activated by TGF-β and is implicated in carcinogenesis regulation. (RefSeq, Apr 2009) |
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